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Table 2 Hazard ratios (HR) of parkinsonism by exposure to disulfiram and neuroleptics therapy

From: Exposure to disulfiram and incidence of parkinsonism

 

N parkinsonism cases

Person-years

Model 1a

Model 2b

Model 3c

HR

95% CI

HR

95% CI

HR

95% CI

Disulfiram

Unexposed

19,064

15,020,303

1

 

1

 

1

 

Exposed

8

5,382

3.103

1.551–6.207

2.037

1.013–4.095

2.040

1.015–4.101

Neuroleptics

Unexposed

16,665

14,670,915

  

1

 

1

 

Exposed

2,407

354,770

  

4.095

3.984–4.362

4.180

3.995–4.374

  1. a adjusted for sex (strata), age and age squared
  2. b adjusted for sex (strata), age, age squared and neuroleptic exposure
  3. c adjusted for sex (strata), age, age squared, neuroleptic exposure and educational attainment
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Journal of Occupational Medicine and Toxicology

ISSN: 1745-6673