Cumulative risk assessment methodology applied to non-dietary exposures: developmental alterations in professional agricultural settings

Tosti, Luca; Marazzini, Martina; Kanadil, Mohammed; Metruccio, Francesca

doi:10.1186/s12995-025-00451-y

Journal of Occupational Medicine and Toxicology

Table 5 Operators, re-entry workers and bystanders’ single substance estimated exposure data (mg/kg bw per day)

From: Cumulative risk assessment methodology applied to non-dietary exposures: developmental alterations in professional agricultural settings

ID mixture^a	A.I	AR A.I. kg/ha	Operator		RE-entry worker		Bystander
ID mixture^a	A.I	AR A.I. kg/ha	DA (%)	TOT. EXP	BC^b	WC^c	BC^b	WC^c
2	FENPYRAZAMINE	0.98	10/50	0.012	0.40	2.77	0.00355	0.02814
2	FOLPET	1.48	10/50	0.021	2.45	17.16	0.00536	0.04250
4	FOLPET	2.39	10/50	0.041	0.97	6.76	0.00865	0.06862
4	SPIROXAMINE	0.75	25/70	0.013	0.73	5.09	0.00272	0.02154
6	FOLPET	5.29	10/50	0.129	5.56	38.90	0.01916	0.15189
6	SPIROXAMINE	2.05	25/70	0.017	1.99	13.91	0.00742	0.05886
7	FOLPET	4.77	10/50	0.035	5.01	35.07	0.01727	0.13696
7	SPIROXAMINE	2.46	25/70	0.016	2.39	16.70	0.00891	0.07063
8	FOLPET	0.60	10/50	0.031	0.63	4.41	0.00218	0.01731
8	SPIROXAMINE	0.35	25/70	0.020	0.34	2.38	0.00127	0.01006
9	FOLPET	0.60	10/50	0.031	0.63	4.41	0.00218	0.01731
9	SPIROXAMINE	0.35	25/70	0.020	0.34	2.38	0.00127	0.01006
10	FOLPET	0.65	10/50	0.033	0.68	4.78	0.00235	0.01861
10	SPIROXAMINE	0.39	25/70	0.022	0.38	2.65	0.00140	0.01107
11	MANCOZEB	0.56	10/50	0.021	0.34	2.38	0.00201	0.01596
11	CYMOXANIL	0.06	10/50	0.002	0.08	0.54	0.00020	0.00158
11	FOLPET	0.55	10/50	0.019	0.71	4.98	0.00200	0.01584
12	FOLPET	0.74	10/50	0.027	0.72	5.02	0.00269	0.02130
12	CYMOXANIL	0.21	10/50	0.009	0.27	1.90	0.00076	0.00599
13	FOLPET	0.74	10/50	0.027	0.72	5.02	0.00269	0.02130
13	TEBUCONAZOLE	1.13	10/50	0.040	1.10	7.67	0.00411	0.03257
14	MANCOZEB	0.19	10/50	0.008	0.15	1.07	0.00067	0.00532
14	CYMOXANIL	0.06	10/50	0.044	0.06	0.41	0.00022	0.00172
14	FOLPET	0.40	10/50	0.059	0.39	2.71	0.00145	0.01149
15	FOLPET	0.59	10/50	0.068	0.62	4.34	0.00215	0.01702
15	TEBUCONAZOLE	0.04	25/70	0.001	0.04	0.27	0.00013	0.00102
15	SPIROXAMINE	0.20	25/70	0.007	0.19	1.36	0.00072	0.00567
16	FOLPET	0.74	10/50	0.027	0.72	5.02	0.00269	0.02130
16	TEBUCONAZOLE	1.13	10/50	0.040	1.10	7.67	0.00411	0.03257
17	TEBUCONAZOLE	0.05	25/70	0.001	0.05	0.34	0.00017	0.00136
17	SPIROXAMINE	0.17	25/70	0.004	0.16	1.15	0.00060	0.00479
18	FOLPET	1.13	10/50	0.039	0.46	3.20	0.00410	0.03253
18	TEBUCONAZOLE	0.09	10/50	0.003	0.09	0.61	0.00032	0.00253
19	FOLPET	1.18	10/50	0.033	0.48	3.34	0.00427	0.03385
19	TEBUCONAZOLE	0.01	10/50	0.0004	0.01	0.07	0.00002	0.00016
20	MANCOZEB	1.46	10/50	0.051	1.71	11.97	0.00528	0.04186
20	CYMOXANIL	0.02	10/50	0.038	0.01	0.06	0.00008	0.00065
21	MANCOZEB	1.16	10/50	0.088	1.12	7.87	0.00420	0.03326
21	TEBUCONAZOLE	0.09	10/50	0.004	0.07	0.48	0.00031	0.00244
22	MANCOZEB	1.03	10/50	0.087	1.00	6.99	0.00374	0.02963
22	TEBUCONAZOLE	0.48	10/50	0.010	0.47	3.26	0.00174	0.01378
23	FOLPET	0.84	10/50	0.007	0.98	6.89	0.00305	0.02419
23	SPIROXAMINE	0.26	25/70	0.001	0.25	1.76	0.00095	0.00756
24	FOLPET	1.05	10/50	0.007	1.23	8.61	0.00381	0.03024
24	SPIROXAMINE	0.38	25/70	0.002	0.37	2.58	0.00138	0.01096
25	SPIROXAMINE	0.20	25/70	0.001	0.19	1.36	0.00073	0.00578
25	FOLPET	0.72	10/50	0.006	0.70	4.89	0.00262	0.02079
28	FOLPET	2.72	10/50	0.018	5.93	41.54	0.00985	0.07813
28	SPIROXAMINE	0.26	25/70	0.006	0.25	1.76	0.00095	0.00757
29	CYMOXANIL	0.11	10/50	0.001	0.04	0.31	0.00038	0.00305
29	SPIROXAMINE	0.26	25/70	0.005	0.25	1.76	0.00095	0.00757
30	CYMOXANIL	0.11	10/50	0.001	0.04	0.31	0.00038	0.00305
30	ABAMECTINE	0.01	10/50	0.004	0.004	0.03	0.00002	0.00019
31	FOLPET	0.80	10/50	0.012	0.84	5.88	0.00290	0.02295
31	SPIROXAMINE	0.31	25/70	0.007	0.30	2.10	0.00111	0.00881
32	FOLPET	0.80	10/50	0.012	0.84	5.88	0.00290	0.02297
32	SPIROXAMINE	0.35	25/70	0.004	0.34	2.38	0.00127	0.01006
33	FOLPET	0.80	10/50	0.012	0.84	5.88	0.00290	0.02297
33	SPIROXAMINE	0.35	25/70	0.004	0.34	2.38	0.00127	0.01006
34	FOLPET	0.80	10/50	0.012	0.84	5.88	0.00290	0.02297
34	SPIROXAMINE	0.35	25/70	0.004	0.34	2.38	0.00127	0.01008

A.I Active ingredient, AR application rate, DA % of dermal absorption (concentrated/dilution), BC best case, WC worst case, Tot. Exp. total exposure includes dermal and inhalation exposure during mixing&loading, application
^aID mixture: refer to mixtures in grapes
^bDermal Absorption: 10%
^cDermal Absorption: 70%

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ISSN: 1745-6673

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