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Table 2 Histomorphological evaluation of lung samples in the FFE-treated SD rat study. Incidence of preneoplastic pleural nodules or plaques and fibrosis

From: Pathological characterization of lung fibrosis in Sprague–Dawley rats treated with fluoro-edenite fibres by intrapleural injection

Group

Treatment

Dose

(mg/cc H2O)

Route of administration

Animals

Fibrous plaque or nodule

Fibrosis

Sex

No

No

%

No

%

I

Fibrous FE

25

Intrapleural Injection

M

40

3

7.5

27

67.5

    

F

40

3

7.5

24

60.0

    

M + F

80

6

7.5

51

63.8

II

-

0

Injection with water

M

40

0

-

0

-

  

(control)

 

F

40

0

-

0

-

    

M + F

80

0

-

0

-

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Journal of Occupational Medicine and Toxicology

ISSN: 1745-6673