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Table 1 Assessment of toxicity of various concentrations of leupeptin and other agents on ABR thresholds before and 3 days after middle ear application for 5 consecutive days.

From: Leupeptin reduces impulse noise induced hearing loss

Agent

Concentration

No Ears

ABR Threshold (dB pe SPL)*

Clinical observation

   

Baseline

After Application

 

Leupeptin

15%

3**

55

120

Ipsilateral head tilt, bloody otorrhea

 

1%

2

55

115

Bloody otorrhea

 

0.1%

3**

56.7

60

Bloody otorrhea

 

0.01%

3**

50

55

 

Gentamicin

4%

6

50

111.6

 

Saline

0.9%

6

50

56.7

 
  1. * No response was calculated as 120 dB
  2. **One animal died after 3rd injection.
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Journal of Occupational Medicine and Toxicology

ISSN: 1745-6673